Title |
T helper cell mediated-tolerance towards fetal allograft in successful pregnancy
|
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Published in |
Clinical and Molecular Allergy, June 2015
|
DOI | 10.1186/s12948-015-0015-y |
Pubmed ID | |
Authors |
Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Sergio Romagnani, Philippe Le Bouteiller |
Abstract |
Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsible for acute allograft rejection, could be involved in miscarriage and Th2 cells together with regulatory CD4+ T cells, known to be involved in allograft tolerance, could be responsible, at least in part, for the success of pregnancy. In this review we focus the role effector CD4+ T cells Th1, Th2 and Th17 cells on the fetal allograft tolerance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Student > Master | 7 | 16% |
Researcher | 5 | 11% |
Student > Postgraduate | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Other | 6 | 13% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 27% |
Immunology and Microbiology | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Veterinary Science and Veterinary Medicine | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Other | 4 | 9% |
Unknown | 13 | 29% |