↓ Skip to main content

Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates

Overview of attention for article published in Environmental Health, June 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

1 news outlet
1 policy source
1 tweeter


39 Dimensions

Readers on

65 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates
Published in
Environmental Health, June 2015
DOI 10.1186/s12940-015-0032-9
Pubmed ID

Ulla B. Mogensen, Philippe Grandjean, Carsten Heilmann, Flemming Nielsen, Pál Weihe, Esben Budtz-Jørgensen


Exposure to perfluorinated alkylate substances (PFASs) is associated with immune suppression in animal models, and serum concentrations of specific antibodies against certain childhood vaccines tend to decrease at higher exposures. As such, we investigated the immunotoxic impacts of the three major PFASs in a Faroese birth cohort. A total of 464 children contributed blood samples collected at age 7 years. PFAS concentrations and concentrations of antibodies against diphtheria and tetanus were assessed in serum at age 7 years, and results were available from samples collected at age 5. In addition to standard regressions, structural equation models were generated to determine the association between three major PFASs measured at the two points in time and the two antibody concentrations. Concentrations of all three 7-year PFAS concentrations were individually associated with a decrease in concentrations of antibodies, however, it was not possible to attribute causality to any single PFAS concentration. Hence, the three 7-year concentrations were combined and showed that a 2-fold increase in PFAS was associated with a decrease by 54.4 % (95 % CI: 22.0 %, 73.3 %) in the antibody concentration. If considering both the age-5 and age-7 concentrations of the three major PFASs, the exposure showed a slightly greater loss. These analyses strengthen the evidence of human PFAS immunotoxicity at current exposure levels and reflect the usefulness of structural equation models to adjust for imprecision in the exposure variables.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Ph. D. Student 10 15%
Student > Master 8 12%
Other 5 8%
Student > Bachelor 4 6%
Other 9 14%
Unknown 19 29%
Readers by discipline Count As %
Environmental Science 9 14%
Agricultural and Biological Sciences 7 11%
Medicine and Dentistry 7 11%
Nursing and Health Professions 4 6%
Engineering 3 5%
Other 11 17%
Unknown 24 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2018.
All research outputs
of 20,568,640 outputs
Outputs from Environmental Health
of 1,415 outputs
Outputs of similar age
of 248,981 outputs
Outputs of similar age from Environmental Health
of 1 outputs
Altmetric has tracked 20,568,640 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,415 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them