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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis
|
|---|---|
| Published in |
BMC Medicine, June 2015
|
| DOI | 10.1186/s12916-015-0379-3 |
| Pubmed ID | |
| Authors |
Andrea C Tricco, Charlene Soobiah, Erik Blondal, Areti A Veroniki, Paul A Khan, Afshin Vafaei, John Ivory, Lisa Strifler, Huda Ashoor, Heather MacDonald, Emily Reynen, Reid Robson, Joanne Ho, Carmen Ng, Jesmin Antony, Kelly Mrklas, Brian Hutton, Brenda R Hemmelgarn, David Moher, Sharon E Straus |
| Abstract |
Serotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients, but these agents may be harmful. We conducted a systematic review on the comparative safety of 5-HT3 receptor antagonists. Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564. Overall, 120 studies and 27,787 patients were included after screening of 7,608 citations and 1,014 full-text articles. Significantly more patients receiving granisetron plus dexamethasone experienced an arrhythmia relative to placebo (odds ratio (OR) 2.96, 95 % confidence interval (CI) 1.11-7.94), ondansetron (OR 3.23, 95 % CI 1.17-8.95), dolasetron (OR 4.37, 95 % CI 1.51-12.62), tropisetron (OR 3.27, 95 % CI 1.02-10.43), and ondansetron plus dexamethasone (OR 5.75, 95 % CI 1.71-19.34) in a NMA including 31 randomized clinical trials (RCTs) and 6,623 patients of all ages. No statistically significant differences in delirium frequency were observed across all treatment comparisons in a NMA including 18 RCTs and 3,652 patients. Granisetron plus dexamethasone increases the risk of arrhythmia. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 8 | 73% |
| United Kingdom | 1 | 9% |
| Unknown | 2 | 18% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 5 | 45% |
| Scientists | 3 | 27% |
| Members of the public | 3 | 27% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Colombia | 1 | 1% |
| Canada | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 93 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 10 | 10% |
| Student > Master | 10 | 10% |
| Researcher | 9 | 9% |
| Student > Postgraduate | 7 | 7% |
| Student > Ph. D. Student | 7 | 7% |
| Other | 21 | 22% |
| Unknown | 33 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 43% |
| Nursing and Health Professions | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Agricultural and Biological Sciences | 2 | 2% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 37 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2019.
All research outputs
#2,112,058
of 25,579,912 outputs
Outputs from BMC Medicine
#1,446
of 4,059 outputs
Outputs of similar age
#25,775
of 278,426 outputs
Outputs of similar age from BMC Medicine
#29
of 68 outputs
Altmetric has tracked 25,579,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,059 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.9. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.