Title |
Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
|
---|---|
Published in |
Arthritis Research & Therapy, January 2010
|
DOI | 10.1186/ar2918 |
Pubmed ID | |
Authors |
Mario D Cordero, Manuel De Miguel, Ana M Moreno Fernández, Inés M Carmona López, Juan Garrido Maraver, David Cotán, Lourdes Gómez Izquierdo, Pablo Bonal, Francisco Campa, Pedro Bullon, Plácido Navas, José A Sánchez Alcázar |
Abstract |
Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of fibromyalgia. However, it is still not clear whether oxidative stress is the cause or the effect of the abnormalities documented in fibromyalgia. Furthermore, the role of mitochondria in the redox imbalance reported in fibromyalgia also is controversial. We undertook this study to investigate the role of mitochondrial dysfunction, oxidative stress, and mitophagy in fibromyalgia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 20% |
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 2% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Norway | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 181 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 14% |
Student > Master | 26 | 14% |
Student > Bachelor | 26 | 14% |
Student > Ph. D. Student | 24 | 13% |
Other | 16 | 8% |
Other | 37 | 19% |
Unknown | 34 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 60 | 32% |
Agricultural and Biological Sciences | 26 | 14% |
Biochemistry, Genetics and Molecular Biology | 19 | 10% |
Nursing and Health Professions | 10 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
Other | 27 | 14% |
Unknown | 38 | 20% |