Title |
An immuno-epidemiological model for Johne’s disease in cattle
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Published in |
Veterinary Research, June 2015
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DOI | 10.1186/s13567-015-0190-3 |
Pubmed ID | |
Authors |
Maia Martcheva, Suzanne Lenhart, Shigetoshi Eda, Don Klinkenberg, Eiichi Momotani, Judy Stabel |
Abstract |
To better understand the mechanisms involved in the dynamics of Johne's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium avium ssp. paratuberculosis with an epidemiological model. The underlying variable in the within-host model is the time since infection. Two compartments, infected macrophages and T cells, of the within-host model feed into the epidemiological model through the direct transmission rate, disease-induced mortality rate, the vertical transmission rate, and the shedding of MAP into the environment. The epidemiological reproduction number depends on the within-host bacteria load in a complex way, exhibiting multiple peaks. A possible mechanism to account for the switch in shedding patterns of the bacteria in this disease is included in the within-host model, and its effect can be seen in the epidemiological reproduction model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Lecturer | 2 | 13% |
Professor | 2 | 13% |
Student > Bachelor | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Student > Ph. D. Student | 1 | 7% |
Other | 1 | 7% |
Unknown | 7 | 47% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 2 | 13% |
Mathematics | 2 | 13% |
Physics and Astronomy | 1 | 7% |
Engineering | 1 | 7% |
Unknown | 9 | 60% |