Title |
In Vitro Assessment of Tobacco Smoke Toxicity at the BBB: Do Antioxidant Supplements Have a Protective Role?
|
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Published in |
BMC Neuroscience, September 2011
|
DOI | 10.1186/1471-2202-12-92 |
Pubmed ID | |
Authors |
Mohammed Hossain, Peter Mazzone, William Tierney, Luca Cucullo |
Abstract |
Tobacco smoke (TS) contains highly reactive oxygen species (such as hydrogen peroxide, peroxynitrite, etc), which cause oxidative damage in vascular tissue and may exacerbate inflammatory events leading to the blood-brain barrier damage (BBBD) which accompanies the development of a variety of neurological disorders. Smokers often have elevated leukocyte counts (primarily neutrophils and monocytes), and significant decreases in plasma alpha-tocopherol (vitamin E) and ascorbic acid (vitamin C) levels due to increased anti-oxidative mobilization in response to oxidative stress evoked by TS. For this purpose, using static culture systems and a well-established dynamic in vitro BBB model (DIV-BBB) we tested the hypothesis that antioxidant vitamin supplementation (E and/or C) can protect the BBB during exposure to whole soluble TS. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Malaysia | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
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Student > Master | 7 | 14% |
Researcher | 7 | 14% |
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Student > Bachelor | 5 | 10% |
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Psychology | 4 | 8% |
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