Title |
Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients
|
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Published in |
BMC Pulmonary Medicine, June 2015
|
DOI | 10.1186/s12890-015-0062-7 |
Pubmed ID | |
Authors |
Heather G. Ahlgren, Andrea Benedetti, Jennifer S. Landry, Joanie Bernier, Elias Matouk, Danuta Radzioch, Larry C. Lands, Simon Rousseau, Dao Nguyen |
Abstract |
Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV1, but their clinical significance in adult CF patients is poorly characterized. We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV1, rate of pulmonary exacerbations, CRP levels and clinical scores). In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA. In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 14% |
United States | 1 | 14% |
Venezuela, Bolivarian Republic of | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 107 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 22% |
Student > Master | 19 | 17% |
Student > Bachelor | 13 | 12% |
Researcher | 11 | 10% |
Other | 10 | 9% |
Other | 15 | 14% |
Unknown | 18 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 26% |
Immunology and Microbiology | 16 | 15% |
Agricultural and Biological Sciences | 14 | 13% |
Biochemistry, Genetics and Molecular Biology | 14 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 12 | 11% |
Unknown | 21 | 19% |