Title |
Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia
|
---|---|
Published in |
BMC Infectious Diseases, October 2011
|
DOI | 10.1186/1471-2334-11-279 |
Pubmed ID | |
Authors |
Marin L Schweizer, Jon P Furuno, Anthony D Harris, J Kristie Johnson, Michelle D Shardell, Jessina C McGregor, Kerri A Thom, Sara E Cosgrove, George Sakoulas, Eli N Perencevich |
Abstract |
The high prevalence of methicillin-resistant S. aureus (MRSA) has led clinicians to select antibiotics that have coverage against MRSA, usually vancomycin, for empiric therapy for suspected staphylococcal infections. Clinicians often continue vancomycin started empirically even when methicillin-susceptible S. aureus (MSSA) strains are identified by culture. However, vancomycin has been associated with poor outcomes such as nephrotoxicity, persistent bacteremia and treatment failure. The objective of this study was to compare the effectiveness of vancomycin versus the beta-lactam antibiotics nafcillin and cefazolin among patients with MSSA bacteremia. The outcome of interest for this study was 30-day in-hospital mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 43% |
Canada | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Japan | 1 | <1% |
Switzerland | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 190 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 45 | 23% |
Researcher | 31 | 16% |
Student > Bachelor | 23 | 12% |
Student > Ph. D. Student | 14 | 7% |
Student > Doctoral Student | 13 | 7% |
Other | 40 | 20% |
Unknown | 31 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 100 | 51% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 8% |
Agricultural and Biological Sciences | 14 | 7% |
Immunology and Microbiology | 6 | 3% |
Nursing and Health Professions | 3 | 2% |
Other | 18 | 9% |
Unknown | 40 | 20% |