Title |
Presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients, a prospective cohort study
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Published in |
Critical Care, October 2011
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DOI | 10.1186/cc10489 |
Pubmed ID | |
Authors |
Heleen M Oudemans-van Straaten, Henrik Endeman, Robert J Bosman, Milly E Attema-de Jonge, Marc L van Ogtrop, Durk F Zandstra, Eric JF Franssen |
Abstract |
Tobramycin is one of the components used for selective decontamination of the digestive tract (SDD), applied to prevent colonization and subsequent infections in critically ill patients. Tobramycin is administered in the oropharynx and gastrointestinal tract and is normally not absorbed. However, critical illness may convey gut barrier failure. The aim of the study was to assess the prevalence and amount of tobramycin leakage from the gut into the blood, to quantify tobramycin excretion in urine, and to determine the association of tobramycin leakage with markers of circulation, kidney function and other organ failure. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 50 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 17% |
Student > Doctoral Student | 6 | 12% |
Researcher | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Student > Bachelor | 5 | 10% |
Other | 13 | 25% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 60% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Immunology and Microbiology | 4 | 8% |
Environmental Science | 1 | 2% |
Psychology | 1 | 2% |
Other | 1 | 2% |
Unknown | 10 | 19% |