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Presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients, a prospective cohort study

Overview of attention for article published in Critical Care, October 2011
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Title
Presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients, a prospective cohort study
Published in
Critical Care, October 2011
DOI 10.1186/cc10489
Pubmed ID
Authors

Heleen M Oudemans-van Straaten, Henrik Endeman, Robert J Bosman, Milly E Attema-de Jonge, Marc L van Ogtrop, Durk F Zandstra, Eric JF Franssen

Abstract

Tobramycin is one of the components used for selective decontamination of the digestive tract (SDD), applied to prevent colonization and subsequent infections in critically ill patients. Tobramycin is administered in the oropharynx and gastrointestinal tract and is normally not absorbed. However, critical illness may convey gut barrier failure. The aim of the study was to assess the prevalence and amount of tobramycin leakage from the gut into the blood, to quantify tobramycin excretion in urine, and to determine the association of tobramycin leakage with markers of circulation, kidney function and other organ failure.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Brazil 1 2%
Unknown 50 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 17%
Student > Doctoral Student 6 12%
Researcher 6 12%
Student > Ph. D. Student 6 12%
Student > Bachelor 5 10%
Other 13 25%
Unknown 7 13%
Readers by discipline Count As %
Medicine and Dentistry 31 60%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Immunology and Microbiology 4 8%
Environmental Science 1 2%
Psychology 1 2%
Other 1 2%
Unknown 10 19%