Title |
Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes
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Published in |
BMC Developmental Biology, October 2011
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DOI | 10.1186/1471-213x-11-63 |
Pubmed ID | |
Authors |
Sumantra Chatterjee, Guillaume Bourque, Thomas Lufkin |
Abstract |
Identifying DNA sequences (enhancers) that direct the precise spatial and temporal expression of developmental control genes remains a significant challenge in the annotation of vertebrate genomes. Locating these sequences, which in many cases lie at a great distance from the transcription start site, has been a major obstacle in deciphering gene regulation. Coupling of comparative genomics with functional validation to locate such regulatory elements has been a successful method in locating many such regulatory elements. But most of these studies looked either at a single gene only or the whole genome without focusing on any particular process. The pressing need is to integrate the tools of comparative genomics with knowledge of developmental biology to validate enhancers for developmental transcription factors in greater detail |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Spain | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 50 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 24% |
Researcher | 13 | 24% |
Student > Master | 7 | 13% |
Professor | 4 | 7% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 13% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 28 | 52% |
Biochemistry, Genetics and Molecular Biology | 12 | 22% |
Medicine and Dentistry | 5 | 9% |
Physics and Astronomy | 1 | 2% |
Computer Science | 1 | 2% |
Other | 0 | 0% |
Unknown | 7 | 13% |