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Integrating diverse genomic data using gene sets

Overview of attention for article published in Genome Biology, October 2011
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Title
Integrating diverse genomic data using gene sets
Published in
Genome Biology, October 2011
DOI 10.1186/gb-2011-12-10-r105
Pubmed ID
Authors

Svitlana Tyekucheva, Luigi Marchionni, Rachel Karchin, Giovanni Parmigiani

Abstract

We introduce and evaluate data analysis methods to interpret simultaneous measurement of multiple genomic features made on the same biological samples. Our tools use gene sets to provide an interpretable common scale for diverse genomic information. We show we can detect genetic effects, although they may act through different mechanisms in different samples, and show we can discover and validate important disease-related gene sets that would not be discovered by analyzing each data type individually.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 6%
Germany 2 2%
Italy 1 <1%
Denmark 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Russia 1 <1%
Unknown 103 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 34 29%
Student > Ph. D. Student 32 27%
Professor > Associate Professor 10 9%
Professor 8 7%
Student > Bachelor 8 7%
Other 18 15%
Unknown 7 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 53%
Computer Science 13 11%
Mathematics 12 10%
Biochemistry, Genetics and Molecular Biology 9 8%
Medicine and Dentistry 5 4%
Other 8 7%
Unknown 8 7%