Title |
Polymorphisms in melatonin synthesis pathways: possible influences on depression
|
---|---|
Published in |
Journal of Circadian Rhythms, August 2011
|
DOI | 10.1186/1740-3391-9-8 |
Pubmed ID | |
Authors |
Daniel F Kripke, Caroline M Nievergelt, Greg J Tranah, Sarah S Murray, Michael J McCarthy, Katharine M Rex, Neeta Parimi, John R Kelsoe |
Abstract |
It has been reported that rs4446909, a single nucleotide polymorphism (SNP) in the promoter of acetylserotonin methyltransferase (ASMT), influences the expression of the ASMT enzyme. The common G allele is associated with lower ASMT activity, and therefore, diminishes conversion of N-acetylserotonin to melatonin. The G allele was associated with recurrent depressive disorder in a Polish group. ASMT might also affect bipolar relapse, given evidence that N-acetylserotonin might stimulate TRKB receptors, and TRKB may influence mood relapse in bipolar disorder. Additionally, arylalkylamine N-acetyltransferase (AANAT) polymorphisms have been reported associated with depression, perhaps through their influence upon N-acetylserotonin or melatonin synthesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
United Kingdom | 1 | 1% |
Spain | 1 | 1% |
India | 1 | 1% |
Unknown | 71 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 20% |
Student > Ph. D. Student | 11 | 14% |
Student > Bachelor | 10 | 13% |
Student > Master | 7 | 9% |
Professor | 6 | 8% |
Other | 14 | 18% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 28% |
Agricultural and Biological Sciences | 11 | 14% |
Neuroscience | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Psychology | 4 | 5% |
Other | 9 | 12% |
Unknown | 19 | 25% |