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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety
|
|---|---|
| Published in |
Molecular Brain, July 2015
|
| DOI | 10.1186/s13041-015-0128-8 |
| Pubmed ID | |
| Authors |
Alejandro Pan-Vazquez, Natasha Rye, Mitra Ameri, Bethan McSparron, Gabriella Smallwood, Jordan Bickerdyke, Alex Rathbone, Federico Dajas-Bailador, Maria Toledo-Rodriguez |
| Abstract |
Lack of physical activity and increased levels of stress contribute to the development of multiple physical and mental disorders. An increasing number of studies relate voluntary exercise with greater resilience to psychological stress, a process that is highly regulated by the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanisms underlying the beneficial effects of exercise on stress resilience are still poorly understood. Here we have studied the impact of long term exercise and housing conditions on: a) hippocampal expression of glucocorticoid receptor (Nr3c1), b) epigenetic regulation of Nr3c1 (DNA methylation at the Nr3c1-1F promoter and miR-124 expression), c) anxiety (elevated plus maze, EPM), and d) adrenal gland weight and adrenocorticotropic hormone receptor (Mc2r) expression. Exercise increased Nr3c1 and Nr3c1-1F expression and decreased miR-124 levels in the hippocampus in single-housed mice, suggesting enhanced resilience to stress. The opposite was found for pair-housed animals. Bisulfite sequencing showed virtually no DNA methylation in the Nr3c1-1F promoter region. Single-housing increased the time spent on stretch attend postures. Exercise decreased the time spent at the open arms of the EPM, however, the mobility of the exercise groups was significantly lower. Exercise had opposite effects on the adrenal gland weight of single and pair-housed mice, while it had no effect on adrenal Mc2r expression. These results suggest that exercise exerts a positive impact on stress resilience in single-housed mice that could be mediated by decreasing miR-124 and increasing Nr3c1 expression in the hippocampus. However, pair-housing reverses these effects possibly due to stress from dominance disputes between pairs. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 2% |
| Japan | 1 | <1% |
| Unknown | 123 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 19% |
| Student > Master | 18 | 14% |
| Researcher | 16 | 13% |
| Student > Bachelor | 15 | 12% |
| Student > Doctoral Student | 9 | 7% |
| Other | 16 | 13% |
| Unknown | 28 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 19% |
| Agricultural and Biological Sciences | 23 | 18% |
| Medicine and Dentistry | 13 | 10% |
| Psychology | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 15 | 12% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2016.
All research outputs
#13,764,327
of 23,339,727 outputs
Outputs from Molecular Brain
#481
of 1,135 outputs
Outputs of similar age
#125,660
of 264,579 outputs
Outputs of similar age from Molecular Brain
#11
of 18 outputs
Altmetric has tracked 23,339,727 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,135 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.