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Evaluation of variability in target volume delineation for newly diagnosed glioblastoma: a multi-institutional study from the Korean Radiation Oncology Group

Overview of attention for article published in Radiation Oncology, July 2015
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Title
Evaluation of variability in target volume delineation for newly diagnosed glioblastoma: a multi-institutional study from the Korean Radiation Oncology Group
Published in
Radiation Oncology, July 2015
DOI 10.1186/s13014-015-0439-z
Pubmed ID
Authors

Chan Woo Wee, Wonmo Sung, Hyun-Cheol Kang, Kwan Ho Cho, Tae Jin Han, Bae-Kwon Jeong, Jae-Uk Jeong, Haeyoung Kim, In Ah Kim, Jin Hee Kim, Sung Hwan Kim, Suzy Kim, Dong Soo Lee, Me Yeon Lee, Do Hoon Lim, Hye Li Park, Chang-Ok Suh, Sang Min Yoon, Il Han Kim

Abstract

This study aimed for a collaborative evaluation of variability in the target volumes for glioblastoma, determined and contoured by different radiotherapy (RT) facilities in Korea. Fifteen panels of radiation oncologists from independent institutions contoured the gross target volumes (GTVs) and clinical target volumes (CTVs) for 3-dimensional conformal RT or intensity-modulated RT on each simulation CT images, after scrutinizing the enhanced T1-weighted and T2-weighted-fluid-attenuated inversion recovery MR images of 9 different cases of glioblastoma. Degrees of contouring agreement were analyzed by the kappa statistics. Using the algorithm of simultaneous truth and performance level estimation (STAPLE), GTVSTAPLE and CTVSTAPLE contours were derived. Contour agreement was moderate (mean kappa 0.58) among the GTVs and was substantial (mean kappa 0.65) among the CTVs. However, each panels' GTVs and modification of CTVs regarding anatomical structures varied. Three-fourth of contoured panels' CTVs encompassed the peritumoral areas of T2-high signal intensity (T2-HSI). Nine of nine GTVSTAPLE encompased the surgical cavity and the T1-enhanced lesions. Eight of nine CTVSTAPLE encompassed the peritumoral T2-HSI area. The median MARGIN90 and the median MARGIN95 were 1.4 cm and 1.5 cm, respectively. Moderate to substantial agreement existed in target volumes for 3-dimensional or intensity-modulated RT determined by radiation oncologists in Korea. According to the estimated consensus contours, the initial CTV encompassed the GTV with margin less than 2.0 cm and the whole peritumoral areas of T2-HSI. The findings of our study propose the need for further studies and modified guidelines.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
France 1 2%
Brazil 1 2%
Unknown 60 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 16%
Student > Bachelor 7 11%
Student > Ph. D. Student 6 10%
Professor > Associate Professor 6 10%
Student > Master 6 10%
Other 17 27%
Unknown 11 17%
Readers by discipline Count As %
Medicine and Dentistry 29 46%
Physics and Astronomy 5 8%
Nursing and Health Professions 4 6%
Computer Science 3 5%
Engineering 2 3%
Other 4 6%
Unknown 16 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2015.
All research outputs
#14,231,577
of 22,816,807 outputs
Outputs from Radiation Oncology
#804
of 2,054 outputs
Outputs of similar age
#135,540
of 263,464 outputs
Outputs of similar age from Radiation Oncology
#21
of 58 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,054 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,464 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.