Title |
Low expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients
|
---|---|
Published in |
Journal of Experimental & Clinical Cancer Research, July 2015
|
DOI | 10.1186/s13046-015-0184-z |
Pubmed ID | |
Authors |
Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Andrzej Tukiendorf, Kazimierz Kuliczkowski, Grzegorz Mazur |
Abstract |
Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs, play an essential role in the development and progression of acute leukemia. The aim of the study was to evaluate miR-204 expression in patients with AML at diagnosis and after induction chemotherapy, in comparison to healthy controls. We also investigated, if miR-204 expression correlates with clinical features of AML patients. miR-204 expression has been analyzed using RT-PCR in 95 bone marrow specimens from newly diagnosed AML patients in comparison to 20 healthy subject. We showed down-regulated miR-204 expression in AML patients, which was associated with shorter patients' survival. Higher expression of miR-204 in patients after induction therapy was correlated with complete remission achieving. We showed low miR-204 expression in AML and found it to be an independent prognostic factor in this patient population. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Egypt | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 5 | 14% |
Researcher | 5 | 14% |
Student > Master | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Other | 6 | 17% |
Unknown | 8 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 29% |
Agricultural and Biological Sciences | 5 | 14% |
Medicine and Dentistry | 5 | 14% |
Immunology and Microbiology | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Other | 2 | 6% |
Unknown | 10 | 29% |