Title |
Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1
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Published in |
Nutrition & Metabolism, October 2011
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DOI | 10.1186/1743-7075-8-73 |
Pubmed ID | |
Authors |
Dalel Brahmi, Chayma Bouaziz, Yousra Ayed, Hédi Ben Mansour, Lazhar Zourgui, Hassen Bacha |
Abstract |
Aflatoxin B1 (AFB1) is potent hepatotoxic and hepatocarcinogenic agent. In aflatoxicosis, oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage. The aim of this work was to evaluate the hepatoprotective effect of cactus cladode extract (CCE) on aflatoxin B1-induced liver damage in mice by measuring malondialdehyde (MDA) level, the protein carbonyls generation and the heat shock proteins Hsp 70 and Hsp 27 expressions in liver. We also looked for an eventual protective effect against AFB1-induced genotoxicity as determined by chromosome aberrations test, SOS Chromotest and DNA fragmentation assay. We further evaluated the modulation of p53, bax and bcl2 protein expressions in liver. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 19% |
Researcher | 9 | 13% |
Unspecified | 7 | 10% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 6 | 9% |
Other | 19 | 28% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
Medicine and Dentistry | 7 | 10% |
Unspecified | 7 | 10% |
Chemistry | 5 | 7% |
Other | 14 | 20% |
Unknown | 11 | 16% |