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RETRACTED ARTICLE: A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study

Overview of attention for article published in Diagnostic Pathology, July 2015
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

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2 Facebook pages

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Title
RETRACTED ARTICLE: A histopathological analysis of the epidemiology of coronary atherosclerosis: an autopsy study
Published in
Diagnostic Pathology, July 2015
DOI 10.1186/s13000-015-0324-y
Pubmed ID
Authors

Negin Abedinzadeh, Behnam Pedram, Yasan Sadeghian, Seyed Mohamad Hossein Tabatabaei Nodushan, Maryam Gilasgar, Mahsa Darvish, Aram Mokarizadeh

Abstract

Atherosclerosis accounts for a large proportion of cardiovascular system associated morbidity and mortality. We studied the possible association between the histopathological changes of the coronary atherosclerotic lesions and the risk of sudden cardiac death (SCD) using autopsy cases. We performed an autopsy analysis (n = 13, 4 women, 9 men mean age 67.5 years; age range 56-93 years) of SCD which occurred in patients aged over 50 years during March 2010 to December 2013. The following variables were considered: sex, age, medical history, autopsy findings to macroscopic and histological evaluation of the heart. The autopsies were performed according to standard techniques. In all subjects, the heart was dissected following standard autopsy protocol and a 5 cm section of the right coronary artery (RCA) in the atrio-ventricular groove from its origin, a 5 cm segment of the left anterior descending artery (LADA) distal to the origin of the circumflex artery, but including the region of origin of the circumflex branch and left coronary artery (LCA) from its origin till the circumflex branch were excised, dissected out, fixed in 10 % formalin, marked for identification and sent for histopathological analysis. Atherosclerotic plaques were identified in 6.5 % of specimens, 69.34 % of males and 30.66 % of female. Such plaques were typically concentric and more represented with necrosis, calcification, cholesterol crystals, and giant cells, as well as had a higher inflammatory cell count. Furthermore, intima and media thickness of coronary arteries were significantly higher in studied specimens with visualize the connective tissue layers of the adventitia and the fatty acid containing adipose cells in the periadventitial tissue. Furthermore, the degree of microscopic lesion of atherosclerosis increased proportionally with the increase in the intensity of lipid deposition and with the percentage of collagen in the atherosclerotic plaques. In this study, age estimate to be a risk factor for coronary atherosclerosis in individuals more than 50 years old and may be used to predict SCD. Altogether, an enhanced understanding of the pathobiologic processes responsible for atherosclerotic changes might allow for early identification of a high-risk coronary plaque and thereby provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients and prevention of acute coronary syndromes.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 14%
Student > Postgraduate 6 14%
Student > Master 4 9%
Other 3 7%
Librarian 2 5%
Other 6 14%
Unknown 16 37%
Readers by discipline Count As %
Medicine and Dentistry 17 40%
Biochemistry, Genetics and Molecular Biology 2 5%
Veterinary Science and Veterinary Medicine 1 2%
Nursing and Health Professions 1 2%
Business, Management and Accounting 1 2%
Other 2 5%
Unknown 19 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2015.
All research outputs
#5,996,720
of 22,816,807 outputs
Outputs from Diagnostic Pathology
#143
of 1,126 outputs
Outputs of similar age
#68,678
of 262,956 outputs
Outputs of similar age from Diagnostic Pathology
#14
of 82 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,126 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,956 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.