Title |
Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions
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Published in |
The Journal of Physiological Sciences, June 2017
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DOI | 10.1007/s12576-017-0553-9 |
Pubmed ID | |
Authors |
Tomohiro Mori, Nobuhide Agata, Yuta Itoh, Masumi Inoue-Miyazu, Kazue Mizumura, Masahiro Sokabe, Toru Taguchi, Keisuke Kawakami |
Abstract |
We investigated the cellular mechanisms and therapeutic effect of post-injury stretch on the recovery process from muscle injury induced by lengthening contractions (LC). One day after LC, a single 15-min bout of muscle stretch was applied at an intensity of 3 mNm. The maximal isometric torque was measured before and at 2-21 days after LC. The myofiber size was analyzed at 21 days after LC. Developmental myosin heavy chain-immunoreactive (dMHC-ir) cells, a marker of regenerating myofibers, were observed in the early recovery stage (2-5 days after LC). We observed that LC-induced injury markedly decreased isometric torque and myofiber size, which recovered faster in rats that underwent stretch than in rats that did not. Regenerating myofiber with dMHC-ir cells was observed earlier in rats that underwent stretch. These results indicate that post-injury stretch may facilitate the regeneration and early formation of new myofibers, thereby promoting structural and functional recovery from LC-induced muscle injury. |
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