Title |
Protein release through nonlethal oncotic pores as an alternative nonclassical secretory pathway
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Published in |
BMC Molecular and Cell Biology, October 2011
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DOI | 10.1186/1471-2121-12-46 |
Pubmed ID | |
Authors |
William J Chirico |
Abstract |
Nonclassical (unconventional) protein secretion is thought to represent the primary secretion mechanism for several cytosolic proteins, such as HIV-Tat, galectin 1, interleukin-1β, and several proteins that shuttle between the nucleus and cytosol, such as fibroblast growth factor 1 (FGF1), FGF2, and nucleolin. Four nonclassical secretory pathways have been described including direct transport (presumably through transporters in the plasma membrane), secretion via exosomes, lysosomal secretion, and blebbing. The purpose of this study was to gain mechanistic insight into nonclassical protein secretion using phosphoglycerate kinase 1 (PGK1), a previously identified nonclassical secretory protein, as a reporter protein. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 21% |
Student > Bachelor | 5 | 15% |
Student > Ph. D. Student | 5 | 15% |
Student > Doctoral Student | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Other | 5 | 15% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 41% |
Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Medicine and Dentistry | 2 | 6% |
Chemistry | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 4 | 12% |
Unknown | 5 | 15% |