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Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China

Overview of attention for article published in BMC Infectious Diseases, July 2015
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Title
Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China
Published in
BMC Infectious Diseases, July 2015
DOI 10.1186/s12879-015-0998-5
Pubmed ID
Authors

Rong Wang, Xiao-lei Guo, G. Bea. A. Wisman, Ed Schuuring, Wen-feng Wang, Zheng-yu Zeng, Hong Zhu, Shang-wei Wu

Abstract

Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical cancer among different populations. To establish a foundation for HPV-based screening and vaccination programs in China, we investigated the most recent HPV prevalence and genotypic distributions in different female age groups and geographical regions in China. In 2012, a total of 120,772 liquid-based cytological samples from women enrolled for population- or employee-based cervical screening in 37 Chinese cities were obtained by the Laboratory of Molecular Infectious Diseases of Guangzhou KingMed. A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay. The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region. The regions of Nanchang, Changsha, Hangzhou, Chengdu, Fuzhou, Guangdong, and Guiyang could be considered the low prevalence regions. Age-specific prevalence showed a "two-peak" pattern, with the youngest age group (15-19 years) presenting the highest hrHPV infection rate (30.55 %), followed by a second peak for the 50-60-year-old group. Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %). Two genotypes HPV6 (4.01 %) and HPV11 (2.29 %) were predominant in the low-risk HPV (lrHPV) type, while the mixed genotypes HPV16 + 52 and HPV52 + 58 were most common in women with multiple infections. This study shows that HPV infection in China has increased to the level of an "HPV-heavy-burden" zone in certain regions, with prevalence varying significantly among different ages and regions. Data from this study represent the most current survey of the nationwide prevalence of HPV infection in China, and can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 16%
Student > Master 11 14%
Student > Ph. D. Student 8 11%
Student > Doctoral Student 8 11%
Researcher 6 8%
Other 12 16%
Unknown 19 25%
Readers by discipline Count As %
Medicine and Dentistry 23 30%
Nursing and Health Professions 9 12%
Biochemistry, Genetics and Molecular Biology 6 8%
Immunology and Microbiology 4 5%
Agricultural and Biological Sciences 3 4%
Other 11 14%
Unknown 20 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2015.
All research outputs
#20,724,339
of 23,323,574 outputs
Outputs from BMC Infectious Diseases
#6,599
of 7,805 outputs
Outputs of similar age
#220,594
of 263,939 outputs
Outputs of similar age from BMC Infectious Diseases
#121
of 126 outputs
Altmetric has tracked 23,323,574 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,805 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.