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Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy

Overview of attention for article published in Journal of Neuroinflammation, October 2011
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Title
Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy
Published in
Journal of Neuroinflammation, October 2011
DOI 10.1186/1742-2094-8-144
Pubmed ID
Authors

Paul J Orchard, Troy Lund, Wes Miller, Steven M Rothman, Gerald Raymond, David Nascene, Lisa Basso, James Cloyd, Jakub Tolar

Abstract

Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder characterized by the abnormal beta-oxidation of very long chain fatty acids (VLCFA). In 35-40% of children with ALD, an acute inflammatory process occurs in the central nervous system (CNS) leading to demyelination that is rapidly progressive, debilitating and ultimately fatal. Allogeneic hematopoietic stem cell transplantation (HSCT) can halt disease progression in cerebral ALD (C-ALD) if performed early. In contrast, for advanced patients the risk of morbidity and mortality is increased with transplantation. To date there is no means of quantitating neuroinflammation in C-ALD, nor is there an accepted measure to determine prognosis for more advanced patients.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Student > Ph. D. Student 6 12%
Student > Bachelor 6 12%
Student > Master 6 12%
Student > Doctoral Student 3 6%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Medicine and Dentistry 12 24%
Agricultural and Biological Sciences 8 16%
Biochemistry, Genetics and Molecular Biology 5 10%
Nursing and Health Professions 3 6%
Neuroscience 2 4%
Other 6 12%
Unknown 14 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2011.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Journal of Neuroinflammation
#2,022
of 2,951 outputs
Outputs of similar age
#105,331
of 151,229 outputs
Outputs of similar age from Journal of Neuroinflammation
#21
of 30 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.