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Standardization of the methods and reference materials used to assess virus content in varicella vaccines

Overview of attention for article published in Virology Journal, July 2015
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Title
Standardization of the methods and reference materials used to assess virus content in varicella vaccines
Published in
Virology Journal, July 2015
DOI 10.1186/s12985-015-0333-1
Pubmed ID
Authors

JiYoung Hong, Ho Jung Oh, Naery Lee, Do-Keun Kim, Heui-Seong Yoon, Yeon-Tae Kim, Seokkee Chang, Jae-Hak Park, Hyejoo Chung

Abstract

In Korea, every vaccine lot is tested by the National Center for Lot Release (NCLR) in accordance with the national lot release procedures to ensure the safety and efficacy of vaccines. These quality tests examine the virus content in varicella vaccines via plaque assays (either the agar overlay method [AOM] or plaque staining method [PSM]), according to the procedures suggested by the Korean Reference Material for the Varicella Vaccine (KRMVV) or the manufacturer's standard in-house protocol. To standardize the virus content tests, viral titers in the KRMVV were measured using the PSM at four participating laboratories in a collaborative study. With the aim of developing a standardized method using the KRMVV as a positive control, we compared the ability of the two test methods, AOM and PSM, to accurately and reproducibly determine the virus content of two commercial varicella vaccines. The results showed that the standardized method (PSM) was more suitable for quality control analysis of the varicella vaccine. Use of a standardized method (PSM) according to the Korean reference material will improve the reliability and objectivity of lot release testing.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 42%
Student > Bachelor 1 8%
Librarian 1 8%
Student > Master 1 8%
Student > Ph. D. Student 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 17%
Economics, Econometrics and Finance 2 17%
Immunology and Microbiology 2 17%
Agricultural and Biological Sciences 1 8%
Nursing and Health Professions 1 8%
Other 1 8%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2015.
All research outputs
#18,418,694
of 22,816,807 outputs
Outputs from Virology Journal
#2,438
of 3,043 outputs
Outputs of similar age
#188,587
of 262,401 outputs
Outputs of similar age from Virology Journal
#42
of 47 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,043 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.