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The diagnostic value of iron oxide nanoparticles for imaging of myocardial inflammation – quo vadis?

Overview of attention for article published in Critical Reviews in Diagnostic Imaging, July 2015
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Average Attention Score compared to outputs of the same age and source

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7 X users
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Citations

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52 Mendeley
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Title
The diagnostic value of iron oxide nanoparticles for imaging of myocardial inflammation – quo vadis?
Published in
Critical Reviews in Diagnostic Imaging, July 2015
DOI 10.1186/s12968-015-0165-6
Pubmed ID
Authors

Michael Bietenbeck, Anca Florian, Udo Sechtem, Ali Yilmaz

Abstract

Cardiovascular magnetic resonance (CMR) is an integral part in the diagnostic work-up of cardiac inflammatory diseases. In this context, superparamagnetic iron oxide-based contrast agents can provide additional diagnostic information regarding the assessment of myocardial infarction and myocarditis. After intravenous administration, these nanoparticles are taken up by activated monocytes and macrophages, which predominantly accumulate in regions associated with inflammation as was successfully shown in recent preclinical studies. Furthermore, first clinical studies with a new iron oxide-complex that was clinically approved for the treatment of iron deficiency anaemia recently demonstrated a superior diagnostic value of iron oxide nanoparticles compared to gadolinium-based compounds for imaging of myocardial inflammation in patients with acute myocardial infarction. In this article, we outline the basic features of superparamagnetic iron oxide-based contrast agents and review recent studies using such nanoparticles for cardiac imaging in case of acute myocardial infarction as well as acute myocarditis. Moreover, we highlight the translational potential of these agents and possible research applications with regard to imaging and therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 4%
Netherlands 1 2%
Chile 1 2%
France 1 2%
Russia 1 2%
United States 1 2%
Unknown 45 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 7 13%
Student > Bachelor 6 12%
Professor > Associate Professor 4 8%
Student > Master 4 8%
Other 10 19%
Unknown 11 21%
Readers by discipline Count As %
Medicine and Dentistry 16 31%
Engineering 4 8%
Agricultural and Biological Sciences 4 8%
Biochemistry, Genetics and Molecular Biology 3 6%
Chemistry 3 6%
Other 10 19%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2015.
All research outputs
#7,480,934
of 25,711,518 outputs
Outputs from Critical Reviews in Diagnostic Imaging
#576
of 1,386 outputs
Outputs of similar age
#80,184
of 276,809 outputs
Outputs of similar age from Critical Reviews in Diagnostic Imaging
#19
of 34 outputs
Altmetric has tracked 25,711,518 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,386 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,809 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.