Title |
Casein kinase 1α: biological mechanisms and theranostic potential
|
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Published in |
Cell Communication and Signaling, May 2018
|
DOI | 10.1186/s12964-018-0236-z |
Pubmed ID | |
Authors |
Shaojie Jiang, Miaofeng Zhang, Jihong Sun, Xiaoming Yang |
Abstract |
Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1α is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1α, and provide an overview of existing challenges and potential opportunities for advancing theranostics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 107 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 16% |
Student > Bachelor | 15 | 14% |
Researcher | 11 | 10% |
Student > Master | 11 | 10% |
Student > Doctoral Student | 8 | 7% |
Other | 10 | 9% |
Unknown | 35 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 34 | 32% |
Medicine and Dentistry | 11 | 10% |
Chemistry | 6 | 6% |
Agricultural and Biological Sciences | 6 | 6% |
Immunology and Microbiology | 6 | 6% |
Other | 11 | 10% |
Unknown | 33 | 31% |