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Discovery of dominant and dormant genes from expression data using a novel generalization of SNR for multi-class problems

Overview of attention for article published in BMC Bioinformatics, October 2008
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Title
Discovery of dominant and dormant genes from expression data using a novel generalization of SNR for multi-class problems
Published in
BMC Bioinformatics, October 2008
DOI 10.1186/1471-2105-9-425
Pubmed ID
Authors

Yu-Shuen Tsai, Chin-Teng Lin, George C Tseng, I-Fang Chung, Nikhil Ranjan Pal

Abstract

The Signal-to-Noise-Ratio (SNR) is often used for identification of biomarkers for two-class problems and no formal and useful generalization of SNR is available for multiclass problems. We propose innovative generalizations of SNR for multiclass cancer discrimination through introduction of two indices, Gene Dominant Index and Gene Dormant Index (GDIs). These two indices lead to the concepts of dominant and dormant genes with biological significance. We use these indices to develop methodologies for discovery of dominant and dormant biomarkers with interesting biological significance. The dominancy and dormancy of the identified biomarkers and their excellent discriminating power are also demonstrated pictorially using the scatterplot of individual gene and 2-D Sammon's projection of the selected set of genes. Using information from the literature we have shown that the GDI based method can identify dominant and dormant genes that play significant roles in cancer biology. These biomarkers are also used to design diagnostic prediction systems.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Taiwan 1 3%
Australia 1 3%
Unknown 29 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 25%
Student > Ph. D. Student 5 16%
Professor 4 13%
Student > Master 3 9%
Professor > Associate Professor 2 6%
Other 3 9%
Unknown 7 22%
Readers by discipline Count As %
Computer Science 8 25%
Engineering 5 16%
Medicine and Dentistry 4 13%
Biochemistry, Genetics and Molecular Biology 3 9%
Agricultural and Biological Sciences 2 6%
Other 2 6%
Unknown 8 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2011.
All research outputs
#15,237,301
of 22,655,397 outputs
Outputs from BMC Bioinformatics
#5,353
of 7,236 outputs
Outputs of similar age
#76,217
of 89,879 outputs
Outputs of similar age from BMC Bioinformatics
#33
of 40 outputs
Altmetric has tracked 22,655,397 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,236 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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