Title |
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen
|
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Published in |
BMC Microbiology, October 2011
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DOI | 10.1186/1471-2180-11-234 |
Pubmed ID | |
Authors |
Marc Le Breton, Laurène Meyniel-Schicklin, Alexandre Deloire, Bruno Coutard, Bruno Canard, Xavier de Lamballerie, Patrice Andre, Chantal Rabourdin-Combe, Vincent Lotteau, Nathalie Davoust |
Abstract |
The genus Flavivirus encompasses more than 50 distinct species of arthropod-borne viruses, including several major human pathogens, such as West Nile virus, yellow fever virus, Japanese encephalitis virus and the four serotypes of dengue viruses (DENV type 1-4). Each year, flaviviruses cause more than 100 million infections worldwide, some of which lead to life-threatening conditions such as encephalitis or haemorrhagic fever. Among the viral proteins, NS3 and NS5 proteins constitute the major enzymatic components of the viral replication complex and are essential to the flavivirus life cycle. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Germany | 1 | <1% |
Italy | 1 | <1% |
French Polynesia | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
China | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 172 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 29% |
Researcher | 28 | 15% |
Student > Master | 24 | 13% |
Student > Bachelor | 15 | 8% |
Student > Doctoral Student | 11 | 6% |
Other | 32 | 18% |
Unknown | 20 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 75 | 41% |
Biochemistry, Genetics and Molecular Biology | 33 | 18% |
Immunology and Microbiology | 14 | 8% |
Medicine and Dentistry | 12 | 7% |
Veterinary Science and Veterinary Medicine | 9 | 5% |
Other | 17 | 9% |
Unknown | 22 | 12% |