Title |
Exosomes in cancer: small particle, big player
|
---|---|
Published in |
Journal of Hematology & Oncology, July 2015
|
DOI | 10.1186/s13045-015-0181-x |
Pubmed ID | |
Authors |
Xu Zhang, Xiao Yuan, Hui Shi, Lijun Wu, Hui Qian, Wenrong Xu |
Abstract |
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the exchange of genetic information and reprogramming of the recipient cells. Increasing evidence suggests that tumor cells release excessive amount of exosomes, which may influence tumor initiation, growth, progression, metastasis, and drug resistance. In addition, exosomes transfer message from tumor cells to immune cells and stromal cells, contributing to the escape from immune surveillance and the formation of tumor niche. In this review, we highlight the recent advances in the biology of exosomes as cancer communicasomes. We review the multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment. Given that exosomes are cell type specific, stable, and accessible from body fluids, exosomes may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Switzerland | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 3 | <1% |
United States | 3 | <1% |
Brazil | 2 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 718 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 149 | 20% |
Student > Master | 106 | 15% |
Researcher | 91 | 12% |
Student > Bachelor | 86 | 12% |
Student > Doctoral Student | 52 | 7% |
Other | 99 | 14% |
Unknown | 148 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 207 | 28% |
Agricultural and Biological Sciences | 119 | 16% |
Medicine and Dentistry | 75 | 10% |
Engineering | 31 | 4% |
Immunology and Microbiology | 29 | 4% |
Other | 96 | 13% |
Unknown | 174 | 24% |