Title |
The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease
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Published in |
AIDS Research and Therapy, July 2015
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DOI | 10.1186/s12981-015-0063-x |
Pubmed ID | |
Authors |
Signar Mäkitalo, Åsa Mellgren, Ellen Borgh, Lena Kilander, Tobias Skillbäck, Henrik Zetterberg, Magnus Gisslén |
Abstract |
It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of Aβ42 and normal levels of CSF neurofilament light protein and sAPPα and sAPPβ, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 35 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 19% |
Student > Ph. D. Student | 6 | 16% |
Researcher | 5 | 14% |
Student > Bachelor | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Other | 4 | 11% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 32% |
Neuroscience | 5 | 14% |
Agricultural and Biological Sciences | 2 | 5% |
Psychology | 2 | 5% |
Nursing and Health Professions | 1 | 3% |
Other | 5 | 14% |
Unknown | 10 | 27% |