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X Demographics
Mendeley readers
Attention Score in Context
| Title |
White matter injury restoration after stem cell administration in subcortical ischemic stroke
|
|---|---|
| Published in |
Stem Cell Research & Therapy, June 2015
|
| DOI | 10.1186/s13287-015-0111-4 |
| Pubmed ID | |
| Authors |
Laura Otero-Ortega, María Gutiérrez-Fernández, Jaime Ramos-Cejudo, Berta Rodríguez-Frutos, Blanca Fuentes, Tomás Sobrino, Teresa Navarro Hernanz, Francisco Campos, Juan Antonio López, Sebastián Cerdán, Jesús Vázquez, Exuperio Díez-Tejedor |
| Abstract |
Despite its high incidence, nerve fiber (axon and myelin) damage after cerebral infarct has not yet been deeply investigated. To investigate white matter repair after adipose-derived mesenchymal stem cell (ADMSC) administration in an experimental model of subcortical stroke. Moreover, to analyze the ADMSC secretome could be implicated in this repair function. An animal model of subcortical ischemic stroke with white matter affectation was induced in rats by injection of Endothelin-1. At 24 h, 2x10(6) ADMSC were administered ((i.v.) to the treatment group. Functional evaluation, lesion size, fiber tract integrity, cell death, proliferation, white matter repair markers [Oligodendrocyte Transcription factor (Olig-2), Neurofilament (NF), Myelin basic protein (MBP)] and NogoA were all studied after sacrifice (7d and 28d). ADMSC migration and implantation to the brain as well as proteomics analysis and functions of the secretome were also analyzed. Neither ADMSC migration nor implantation to the brain was observed after ADMSC administration. By contrast, ADMSC implantation was detected in peripheral organs. Treated group showed a smaller functional deficit, smaller lesion area, less cell death, more oligodendrocyte proliferation, more white matter connectivity and higher amount of myelin formation. The treated animals also showed higher levels of white matter-associated markers in the injured area than the control group. Proteomics analysis of the ADMSC secretome identified 2,416 proteins, not all of them previously described to be involved in brain plasticity. The conclusion of this study was that white matter integrity in subcortical stroke is in part restored by ADMSC treatment, mediated by repair molecular factors implicated in axonal sprouting, remyelination and oligodendrogenesis. These findings are associated with improved functional recovery after stroke. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 17% |
| Researcher | 10 | 13% |
| Student > Ph. D. Student | 9 | 12% |
| Student > Doctoral Student | 5 | 7% |
| Student > Master | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 22 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 16% |
| Medicine and Dentistry | 9 | 12% |
| Agricultural and Biological Sciences | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 24 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2016.
All research outputs
#3,162,523
of 22,817,213 outputs
Outputs from Stem Cell Research & Therapy
#276
of 2,418 outputs
Outputs of similar age
#42,499
of 264,768 outputs
Outputs of similar age from Stem Cell Research & Therapy
#9
of 39 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,768 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.