A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes

Orphan gene

Orphan genes, ORFans, or taxonomically restricted genes (TRGs) are genes that lack a detectable homologue outside of a given species or lineage.

Orphan gene

Orphan genes, ORF ans, or taxonomically restricted genes (TRGs) are genes that lack a detectable homologue outside of a given species or lineage.

Infiriendo transferencia genética horizontal

Inferring horizontal gene transfer

To infer HGT events, which may not necessarily result in phenotypic changes, most contemporary methods are based on analyses of genomic sequence data.