Title |
Metal nanoparticles: understanding the mechanisms behind antibacterial activity
|
---|---|
Published in |
Journal of Nanobiotechnology, October 2017
|
DOI | 10.1186/s12951-017-0308-z |
Pubmed ID | |
Authors |
Yael N. Slavin, Jason Asnis, Urs O. Häfeli, Horacio Bach |
Abstract |
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1737 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 255 | 15% |
Student > Master | 187 | 11% |
Student > Bachelor | 148 | 9% |
Researcher | 147 | 8% |
Student > Doctoral Student | 74 | 4% |
Other | 232 | 13% |
Unknown | 694 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 200 | 12% |
Biochemistry, Genetics and Molecular Biology | 161 | 9% |
Materials Science | 110 | 6% |
Agricultural and Biological Sciences | 82 | 5% |
Engineering | 76 | 4% |
Other | 308 | 18% |
Unknown | 800 | 46% |