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Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

Overview of attention for article published in Alzheimer's Research & Therapy, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

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2 tweeters
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1 patent

Citations

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111 Dimensions

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140 Mendeley
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Title
Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease
Published in
Alzheimer's Research & Therapy, January 2009
DOI 10.1186/alzrt6
Pubmed ID
Authors

Roy O Weller, Stephen D Preston, Malavika Subash, Roxana O Carare

Abstract

Amyloid is deposited in the walls of arteries and capillaries as cerebral amyloid angiopathy (CAA) in the brains of older individuals and of those with Alzheimer disease (AD). CAA in AD reflects an age-related failure of elimination of amyloid-beta (Abeta) from the brain along perivascular lymphatic drainage pathways. In the absence of conventional lymphatic vessel in the brain, interstitial fluid and solutes drain from the brain to cervical lymph nodes along narrow basement membranes in the walls of capillaries and arteries, a pathway that is largely separate from the cerebrospinal fluid. In this review we focus on the pathology and pathogenesis of CAA, its role in the aetiology of AD and its impact on immunotherapy for AD. The motive force for lymphatic drainage of the brain appears to be generated by arterial pulsations. Failure of elimination of Abeta along perivascular pathways coincides with a reduction in enzymic degradation of Abeta, reduced absorption of Abeta into the blood and age-related stiffening of artery walls that appears to reduce the motive force for lymphatic drainage. Reduced clearances of Abeta and CAA are associated with the accumulation of insoluble and soluble Abetas in the brain in AD and the probable loss of homeostasis of the neuronal environment due to retention of soluble metabolites within the brain. Tau metabolism may also be affected. Immunotherapy has been successful in removing insoluble plaques of Abeta from the brain in AD but with little effect on cognitive decline. One major problem is the increase in CAA in immunised patients that probably prevents the complete removal of Abeta from the brain. Increased knowledge of the physiology and structural and genetic aspects of the lymphatic drainage of Abeta from the brain will stimulate the development of therapeutic strategies for the prevention and treatment of AD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
United States 2 1%
Korea, Republic of 2 1%
South Africa 1 <1%
India 1 <1%
Netherlands 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 128 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 23%
Researcher 20 14%
Student > Master 16 11%
Student > Bachelor 13 9%
Student > Doctoral Student 11 8%
Other 35 25%
Unknown 13 9%
Readers by discipline Count As %
Medicine and Dentistry 42 30%
Agricultural and Biological Sciences 35 25%
Neuroscience 24 17%
Biochemistry, Genetics and Molecular Biology 9 6%
Engineering 4 3%
Other 9 6%
Unknown 17 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2015.
All research outputs
#3,442,244
of 14,191,540 outputs
Outputs from Alzheimer's Research & Therapy
#486
of 661 outputs
Outputs of similar age
#25,496
of 109,637 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 1 outputs
Altmetric has tracked 14,191,540 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 661 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.2. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them