Title |
Biomarkers for immune thrombocytopenia
|
---|---|
Published in |
Biomarker Research, July 2015
|
DOI | 10.1186/s40364-015-0045-0 |
Pubmed ID | |
Authors |
Lingjia Yu, Chunmei Zhang, Liping Zhang, Yongyu Shi, Xuebin Ji |
Abstract |
Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient's immune system is activated by platelet autoantigens resulting in immune mediated platelet destruction or suppression of platelet production. The autoantibodies produced by autoreactive B cells against self antigens are considered to play a crucial role. In addition, biomarkers such as transforming growth factor-beta1,Toll-like receptors,T helper 1 andT helper 2 cytokine bias, Notch signaling and abnormal biomarker in megakaryocyte maturation are involved in the pathogenesis of this disease. With the genomewide association study on immune thrombocytopenia, more biomarkers will be founded in the future. They may provides a theoretical basis for the mechanism and treatment of immune thrombocytopenia. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 21% |
Student > Bachelor | 5 | 21% |
Other | 3 | 13% |
Researcher | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 5 | 21% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 33% |
Biochemistry, Genetics and Molecular Biology | 6 | 25% |
Agricultural and Biological Sciences | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 4 | 17% |
Unknown | 2 | 8% |