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Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline

Overview of attention for article published in Respiratory Research, August 2006
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
90 Dimensions

Readers on

mendeley
96 Mendeley
citeulike
1 CiteULike
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Title
Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline
Published in
Respiratory Research, August 2006
DOI 10.1186/1465-9921-7-112
Pubmed ID
Authors

Dong-Won Lee, Shawna A Shirley, Richard F Lockey, Shyam S Mohapatra

Abstract

Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse side effects. It was hypothesized that adsorption of theophylline to chitosan nanoparticles modified by the addition of thiol groups would improve theophylline absorption by the bronchial epithelium and enhance its anti-inflammatory effects. We sought to develop an improved drug-delivery matrix for theophylline based on thiolated chitosan, and to investigate whether thiolated chitosan nanoparticles (TCNs) can enhance theophylline's capacity to alleviate allergic asthma. A mouse model of allergic asthma was used to test the effects of theophylline in vivo. BALB/c mice were sensitized to ovalbumin (OVA) and OVA-challenged to produce an inflammatory allergic condition. They were then treated intranasally with theophylline alone, chitosan nanoparticles alone or theophylline adsorbed to TCNs. The effects of theophylline on cellular infiltration in bronchoalveolar lavage (BAL) fluid, histopathology of lung sections, and apoptosis of lung cells were investigated to determine the effectiveness of TCNs as a drug-delivery vehicle for theophylline. Theophylline alone exerts a moderate anti-inflammatory effect, as evidenced by the decrease in eosinophils in BAL fluid, the reduction of bronchial damage, inhibition of mucus hypersecretion and increased apoptosis of lung cells. The effects of theophylline were significantly enhanced when the drug was delivered by TCNs. Intranasal delivery of theophylline complexed with TCNs augmented the anti-inflammatory effects of the drug compared to theophylline administered alone in a mouse model of allergic asthma. The beneficial effects of theophylline in treating asthma may be enhanced through the use of this novel drug delivery system.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 4 4%
United States 2 2%
Russia 1 1%
Unknown 89 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Student > Master 22 23%
Researcher 17 18%
Student > Bachelor 8 8%
Student > Postgraduate 5 5%
Other 10 10%
Unknown 11 11%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 17 18%
Agricultural and Biological Sciences 17 18%
Chemistry 13 14%
Medicine and Dentistry 10 10%
Biochemistry, Genetics and Molecular Biology 8 8%
Other 15 16%
Unknown 16 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2018.
All research outputs
#3,850,405
of 13,055,201 outputs
Outputs from Respiratory Research
#508
of 1,546 outputs
Outputs of similar age
#103,135
of 271,538 outputs
Outputs of similar age from Respiratory Research
#8
of 18 outputs
Altmetric has tracked 13,055,201 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,546 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,538 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.