Title |
Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature
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Published in |
BMC Cancer, July 2015
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DOI | 10.1186/s12885-015-1536-y |
Pubmed ID | |
Authors |
Ning Jia, Fionnuala C. Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R. Gralow |
Abstract |
Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological variant, collapsing focal segmental glomerulosclerosis (CFSGS). We describe a breast cancer patient who developed heavy proteinuria (protein/creatinine ratio 9.1) and nephrotic syndrome following treatment with oral ibandronate for 29 months. CFSGS was proven by biopsy. There was no improvement 1 month after ibandronate was discontinued. Prednisone and tacrolimus were started and she experienced a decreased in proteinuria. In patient who develops ibandronate-associated CFSGS, proteinuria appears to be at least partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped. |
X Demographics
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Netherlands | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Master | 4 | 11% |
Student > Bachelor | 4 | 11% |
Researcher | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Other | 7 | 19% |
Unknown | 10 | 28% |
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Unspecified | 1 | 3% |
Other | 4 | 11% |
Unknown | 10 | 28% |