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Sunitinib induced pyoderma gangrenosum-like ulcerations

Overview of attention for article published in European Journal of Medical Research, November 2011
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Title
Sunitinib induced pyoderma gangrenosum-like ulcerations
Published in
European Journal of Medical Research, November 2011
DOI 10.1186/2047-783x-16-11-491
Pubmed ID
Authors

S. Akanay-Diesel, N. P. Hoff, S. Kürle, J. Haes, A. Erhardt, D. Häussinger, K-W. Schulte, E. Bölke, C. Matuschek, W. Budach, P. A. Gerber, B. Homey

Abstract

Pyoderma gangrenosum is a non-infectious neutro?philic skin disease commonly associated with underlying systemic diseases. Histopathological and laboratory diagnostics are unspecific in the majority of the cases and the diagnosis is made in accordance with the clinical picture. Here, we report the case of a 69-year old man with progredient pyoderma gangrenosum-like ulcerations under treatment with sunitinib due to hepatocellular carcinoma. A conventional ulcer therapy did not lead to a regression of the lesions. Solely cessation of sunitinib therapy resulted in an improvement of the ulcerations. Sunitinib is a multikinase inhibitor that targets the PDGF-α- and ?β-, VEGF-1-3-, KIT-, FLT3-, CSF-1- and RET-receptor, thereby impairing tumour proliferation, pathological angiogenesis and metastasation. Here, we demonstrate that pyoderma gangrenosum-like ulcers may represent a serious side effect of sunitinib-based anti-cancer treatment.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 19%
Student > Master 3 14%
Librarian 3 14%
Other 2 10%
Student > Ph. D. Student 2 10%
Other 5 24%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 10 48%
Biochemistry, Genetics and Molecular Biology 2 10%
Unspecified 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Economics, Econometrics and Finance 1 5%
Other 1 5%
Unknown 5 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2011.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from European Journal of Medical Research
#440
of 923 outputs
Outputs of similar age
#107,044
of 154,842 outputs
Outputs of similar age from European Journal of Medical Research
#8
of 8 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 923 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,842 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.