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EqualTDRL: illustrating equivalent tandem duplication random loss rearrangements

Overview of attention for article published in BMC Bioinformatics, May 2018
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Title
EqualTDRL: illustrating equivalent tandem duplication random loss rearrangements
Published in
BMC Bioinformatics, May 2018
DOI 10.1186/s12859-018-2170-x
Pubmed ID
Authors

Tom Hartmann, Matthias Bernt, Martin Middendorf

Abstract

To study the differences between two unichromosomal circular genomes, e.g., mitochondrial genomes, under the tandem duplication random loss (TDRL) rearrangement it is important to consider the whole set of potential TDRL rearrangement events that could have taken place. The reason is that for two given circular gene orders there can exist different TDRL rearrangements that transform one of the gene orders into the other. Hence, a TDRL event cannot always be reconstructed only from the knowledge of the circular gene order before a TDRL event and the circular gene order after it. We present the program EqualTDRL that computes and illustrates the complete set of TDRLs for pairs of circular gene orders that differ by only one TDRL. EqualTDRL considers the circularity of the given genomes and certain restrictions on the TDRL rearrangements. Examples for the latter are sequences of genes that have to be conserved during a TDRL or pairs of genes that frame intergenic regions which might represent remnants of duplicated genes. Additionally, EqualTDRL allows to determine the set of TDRLs that are minimum with respect to the number of duplicated genes. EqualTDRL supports scientists to study the complete set of TDRLs that possibly could have taken place in the evolution of mitochondrial genomes. EqualTDRL is implemented in C++ using the ggplot2 package of the open source programming language R and is freely available from http://pacosy.informatik.uni-leipzig.de/equaltdrl .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Master 2 22%
Professor 1 11%
Student > Doctoral Student 1 11%
Student > Bachelor 1 11%
Other 1 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 44%
Biochemistry, Genetics and Molecular Biology 2 22%
Computer Science 1 11%
Earth and Planetary Sciences 1 11%
Chemistry 1 11%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2018.
All research outputs
#20,516,195
of 23,083,773 outputs
Outputs from BMC Bioinformatics
#6,898
of 7,323 outputs
Outputs of similar age
#290,476
of 331,095 outputs
Outputs of similar age from BMC Bioinformatics
#93
of 108 outputs
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