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Mendeley readers
Attention Score in Context
| Title |
Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
|
|---|---|
| Published in |
Journal of Neurodevelopmental Disorders, August 2011
|
| DOI | 10.1007/s11689-011-9087-2 |
| Pubmed ID | |
| Authors |
Silvia De Rubeis, Claudia Bagni |
| Abstract |
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The disease is caused by mutations or loss of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein playing multiple functions in RNA metabolism. The expression of a large set of neuronal mRNAs is altered when FMRP is lost, thus causing defects in neuronal morphology and physiology. FMRP regulates mRNA stability, dendritic targeting, and protein synthesis. At synapses, FMRP represses protein synthesis by forming a complex with the Cytoplasmic FMRP Interacting Protein 1 (CYFIP1) and the cap-binding protein eIF4E. Here, we review the clinical, genetic, and molecular aspects of FXS with a special focus on the receptor signaling that regulates FMRP-dependent protein synthesis. We further discuss the FMRP-CYFIP1 complex and its potential relevance for ID and autism. |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| Portugal | 1 | <1% |
| Netherlands | 1 | <1% |
| Iceland | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 151 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 21% |
| Researcher | 29 | 18% |
| Student > Master | 27 | 17% |
| Student > Bachelor | 21 | 13% |
| Professor | 6 | 4% |
| Other | 22 | 14% |
| Unknown | 21 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 38% |
| Neuroscience | 23 | 14% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Psychology | 10 | 6% |
| Medicine and Dentistry | 9 | 6% |
| Other | 8 | 5% |
| Unknown | 25 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2012.
All research outputs
#5,589,043
of 22,818,766 outputs
Outputs from Journal of Neurodevelopmental Disorders
#221
of 476 outputs
Outputs of similar age
#31,442
of 120,908 outputs
Outputs of similar age from Journal of Neurodevelopmental Disorders
#3
of 6 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 476 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,908 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.