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Morphometric variability of neuroimaging features in Children with Agenesis of the Corpus Callosum

Overview of attention for article published in BMC Neurology, July 2015
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Title
Morphometric variability of neuroimaging features in Children with Agenesis of the Corpus Callosum
Published in
BMC Neurology, July 2015
DOI 10.1186/s12883-015-0382-5
Pubmed ID
Authors

Jason Bennett Neal, Christopher G. Filippi, Richard Mayeux

Abstract

Agenesis of the corpus callosum (ACC) is a developmental brain malformation associated with a wide spectrum of structural brain abnormalities and genetic loci. To characterize the diverse callosal morphologies and malformations of brain development associated with ACC, we report on the neuroimaging findings of 201 individuals diagnosed with corpus callosal abnormalities. We searched through medical records of individuals seen at New York Presbyterian Hospital between 2002 and 2013 and thought to have ACC. We confirmed 201 individuals meeting criteria and used magnetic resonance imaging to characterize morphological variants of the corpus callosum and associated brain malformations. The majority of individuals displayed hypoplasia or dysplasia of the corpus callosum (N = 160, 80 %). Forty-one (20 %) displayed complete agenesis of the corpus callosum with other abnormalities, while only 18 (9 %) displayed complete agenesis without associated brain abnormalities. White matter abnormalities were more frequent in hypoplasia or dysplasia group than complete agenesis (28.2 % vs 9.8 %, p < 0.05). In contrast, hippocampal abnormalities, colpocephaly, and Probst bundles were significantly more frequent in complete agenesis compared to hypoplasia or dysplasia group. Collectively, our results underscore the broad diversity of morphological variants of the corpus callosum and associated brain abnormalities in individuals with ACC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 16%
Student > Ph. D. Student 6 14%
Researcher 5 11%
Student > Doctoral Student 3 7%
Student > Postgraduate 3 7%
Other 9 20%
Unknown 11 25%
Readers by discipline Count As %
Medicine and Dentistry 18 41%
Neuroscience 3 7%
Agricultural and Biological Sciences 3 7%
Psychology 2 5%
Nursing and Health Professions 1 2%
Other 5 11%
Unknown 12 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2016.
All research outputs
#18,420,033
of 22,818,766 outputs
Outputs from BMC Neurology
#1,888
of 2,435 outputs
Outputs of similar age
#189,156
of 263,272 outputs
Outputs of similar age from BMC Neurology
#44
of 61 outputs
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