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Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

Overview of attention for article published in Virology Journal, January 2011
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Mentioned by

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1 tweeter

Citations

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66 Dimensions

Readers on

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44 Mendeley
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Title
Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication
Published in
Virology Journal, January 2011
DOI 10.1186/1743-422x-8-483
Pubmed ID
Authors

Jiangning Liu, Yajun Yang, Yanfeng Xu, Chunmei Ma, Chuan Qin, Lianfeng Zhang

Abstract

Human enterovirus 71 (EV71) infection causes hand, foot and mouth disease in children under 6 years old and this infection occasionally induces severe neurological complications. No vaccines or drugs are clinical available to control EV71 epidemics. In present study, we show that treatment with lycorine reduced the viral cytopathic effect (CPE) on rhabdomyosarcoma (RD) cells by inhibiting virus replication. Analysis of this inhibitory effect of lycorine on viral proteins synthesis suggests that lycorine blocks the elongation of the viral polyprotein during translation. Lycorine treatment of mice challenged with a lethal dose of EV71 resulted in reduction of mortality, clinical scores and pathological changes in the muscles of mice, which were achieved through inhibition of viral replication. When mice were infected with a moderate dose of EV71, lycorine treatment was able to protect them from paralysis. Lycorine may be a potential drug candidate for the clinical treatment of EV71-infected patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
United Kingdom 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Student > Master 6 14%
Student > Postgraduate 5 11%
Student > Bachelor 5 11%
Researcher 4 9%
Other 9 20%
Unknown 7 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 23%
Medicine and Dentistry 6 14%
Biochemistry, Genetics and Molecular Biology 4 9%
Chemistry 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Other 6 14%
Unknown 10 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2011.
All research outputs
#7,852,918
of 12,515,237 outputs
Outputs from Virology Journal
#1,308
of 2,099 outputs
Outputs of similar age
#62,072
of 105,277 outputs
Outputs of similar age from Virology Journal
#13
of 32 outputs
Altmetric has tracked 12,515,237 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,099 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,277 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.