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Amyloid precursor protein: more than just neurodegeneration

Overview of attention for article published in Stem Cell Research & Therapy, October 2011
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Title
Amyloid precursor protein: more than just neurodegeneration
Published in
Stem Cell Research & Therapy, October 2011
DOI 10.1186/scrt80
Pubmed ID
Authors

Sanjay W Pimplikar, Kaushik Ghosal

Abstract

Amyloid precursor protein (APP) fascinates cell biologists because it is proteolytically processed to generate multiple peptides, including amyloid-β, which is implicated in Alzheimer's disease. However, a large body of data also shows that the extracellular soluble fragment of APP produced by α-secretase (sAPPα) is neuroprotective and promotes neuronal outgrowth. A study by Demars and colleagues appearing in the previous issue provides data showing that sAPPα is a general growth factor for stem cells of multiple lineages. Thus, APP seems to play complex and disparate roles in neurodegeneration and neuroprotection.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Australia 1 6%
Unknown 16 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 33%
Student > Bachelor 3 17%
Researcher 3 17%
Professor 2 11%
Professor > Associate Professor 1 6%
Other 1 6%
Unknown 2 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Neuroscience 5 28%
Medicine and Dentistry 3 17%
Economics, Econometrics and Finance 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 1 6%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2011.
All research outputs
#15,237,301
of 22,655,397 outputs
Outputs from Stem Cell Research & Therapy
#1,326
of 2,410 outputs
Outputs of similar age
#94,517
of 136,368 outputs
Outputs of similar age from Stem Cell Research & Therapy
#5
of 7 outputs
Altmetric has tracked 22,655,397 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,410 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,368 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.