Title |
PIGS: improved estimates of identity-by-descent probabilities by probabilistic IBD graph sampling
|
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Published in |
BMC Bioinformatics, March 2015
|
DOI | 10.1186/1471-2105-16-s5-s9 |
Pubmed ID | |
Authors |
Danny S Park, Yael Baran, Farhad Hormozdiari, Celeste Eng, Dara G Torgerson, Esteban G Burchard, Noah Zaitlen |
Abstract |
Identifying segments in the genome of different individuals that are identical-by-descent (IBD) is a fundamental element of genetics. IBD data is used for numerous applications including demographic inference, heritability estimation, and mapping disease loci. Simultaneous detection of IBD over multiple haplotypes has proven to be computationally difficult. To overcome this, many state of the art methods estimate the probability of IBD between each pair of haplotypes separately. While computationally efficient, these methods fail to leverage the clique structure of IBD resulting in less powerful IBD identification, especially for small IBD segments. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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United States | 1 | 5% |
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Demographic breakdown
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Student > Ph. D. Student | 9 | 43% |
Student > Master | 4 | 19% |
Student > Bachelor | 3 | 14% |
Researcher | 2 | 10% |
Professor > Associate Professor | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |
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Computer Science | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 3 | 14% |