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Emergency medical genomes: a breakthrough application of precision medicine

Overview of attention for article published in Genome Medicine, July 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

blogs
1 blog
twitter
49 tweeters

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
65 Mendeley
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Title
Emergency medical genomes: a breakthrough application of precision medicine
Published in
Genome Medicine, July 2015
DOI 10.1186/s13073-015-0201-z
Pubmed ID
Authors

Stephen F. Kingsmore, Josh Petrikin, Laurel K. Willig, Erin Guest

Abstract

Today there exist two medical applications where relatively strong evidence exists to support the broad adoption of genome-informed precision medicine. These are the differential diagnosis of single gene diseases and genotype-based selection of patients for targeted cancer therapies. However, despite the availability of the $1000 genome and $700 exome for research, there is as yet little broad uptake of genomic medicine, even in these applications. Significant impediments to mainstream adoption exist, including unavailability in many institutions, lack of scalability in others, a dearth of physician understanding of interpreted genome or exome results or knowledge of how to translate consequent precision medicine care plans, and a lack of test reimbursement. In short, genomic medicine lacks a breakthrough application. Rapid genome sequencing of acutely ill infants with suspected genetic diseases (STATseq) may become that application when scaled to dozens of trios per day without loss of timeliness or accuracy. Also critical for broad adoption is embedding STATseq in software for timely patient ascertainment, augmented intelligence for interpretation, explanation of results for generalist physicians, and dynamic precision medicine decision support.

Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 22%
Other 10 15%
Student > Master 8 12%
Student > Ph. D. Student 4 6%
Student > Doctoral Student 4 6%
Other 9 14%
Unknown 16 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 22%
Medicine and Dentistry 13 20%
Agricultural and Biological Sciences 10 15%
Computer Science 5 8%
Nursing and Health Professions 2 3%
Other 4 6%
Unknown 17 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2018.
All research outputs
#915,701
of 21,744,520 outputs
Outputs from Genome Medicine
#185
of 1,376 outputs
Outputs of similar age
#12,676
of 249,055 outputs
Outputs of similar age from Genome Medicine
#2
of 3 outputs
Altmetric has tracked 21,744,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,055 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.