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Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs

Overview of attention for article published in Virology Journal, June 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

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2 tweeters
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1 patent

Citations

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7 Dimensions

Readers on

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24 Mendeley
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Title
Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs
Published in
Virology Journal, June 2018
DOI 10.1186/s12985-018-1009-4
Pubmed ID
Authors

Amélie D. Zaza, Cécile H. Herbreteau, Christophe N. Peyrefitte

Abstract

Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus (JUNV) in Argentina, Guanarito in Venezuela, Sabiá in Brazil and Chapare in Bolivia, also are responsible for human hemorrhagic fevers. Among these arenaviruses, JUNV caused thousands of human cases until 1991, when the live attenuated Candid #1 vaccine, was used. Other than Candid #1 vaccine, few other therapeutic or prophylactic treatments exist. Therefore, new strategies for production of safe countermeasures with broad spectrum activity are needed. We tested a tri-segmented MACV, a potential vaccine candidate with several mutations, (r3MACV). In cell culture, r3MACV showed a 2-log reduction in infectious virus particle production and the MACV inhibition of INF-1β was removed from the construct and produced by infected cells. Furthermore, in an animal experiment, r3MACV was able to protect 50% of guinea pigs from a simultaneous lethal JUNV challenge. Protected animals didn't display clinical symptoms nor were virus particles found in peripheral blood (day 14) or in organs (day 28 post-inoculation). The r3MACV provided a higher protection than the Candid #1 vaccine. The r3MACV provides a potential countermeasure against two South America arenaviruses responsible of human hemorrhagic fever.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Master 4 17%
Librarian 1 4%
Student > Doctoral Student 1 4%
Student > Ph. D. Student 1 4%
Other 3 13%
Unknown 7 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 17%
Veterinary Science and Veterinary Medicine 3 13%
Nursing and Health Professions 2 8%
Unspecified 1 4%
Environmental Science 1 4%
Other 4 17%
Unknown 9 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2021.
All research outputs
#6,243,034
of 21,168,082 outputs
Outputs from Virology Journal
#667
of 2,888 outputs
Outputs of similar age
#106,423
of 298,166 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 21,168,082 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,888 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them