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Mendeley readers
Attention Score in Context
| Title |
Are biological agents toxic to human chondrocytes and osteocytes?
|
|---|---|
| Published in |
Journal of Orthopaedic Surgery and Research, July 2015
|
| DOI | 10.1186/s13018-015-0264-y |
| Pubmed ID | |
| Authors |
Mehmet Isyar, Bulent Bilir, Ibrahim Yilmaz, Selami Cakmak, Duygu Yasar Sirin, Aliye Yildirim Guzelant, Mahir Mahirogullari |
| Abstract |
The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Primary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as control cultures of chondrocyte and osteocyte, and the other two groups were exposed to BAs administered via the culture medium. Cultured cells were characterized by immunophenotyping. Before and after administration of the agents, the cultures were observed by inverted and environmental scanning electron microscopy (ESEM). The number of live cells and the proliferation rate were monitored by MTT assay. Rituximab and adalimumab were the least toxic agents to chondrocytes, whereas adalimumab and etanercept were to osteocytes. During periods of intense active inflammation, the concentration of the preferred BAs after inhibition of inflammation needs to be emphasized when their effects on cartilage and bone tissue are considered at the cellular level if the clinical practice is to continue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Bachelor | 3 | 13% |
| Professor > Associate Professor | 3 | 13% |
| Student > Doctoral Student | 2 | 9% |
| Other | 7 | 30% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 39% |
| Biochemistry, Genetics and Molecular Biology | 4 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 13% |
| Computer Science | 2 | 9% |
| Engineering | 2 | 9% |
| Other | 0 | 0% |
| Unknown | 3 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2015.
All research outputs
#15,340,815
of 22,818,766 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#646
of 1,368 outputs
Outputs of similar age
#153,726
of 263,145 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#21
of 39 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,368 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,145 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.