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Attention Score in Context
| Title |
Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
|
|---|---|
| Published in |
Molecular Neurodegeneration, July 2015
|
| DOI | 10.1186/s13024-015-0030-y |
| Pubmed ID | |
| Authors |
Long Wang, Shanshan Cheng, Zhenyu Yin, Congyu Xu, Shuangshuang Lu, Jinxing Hou, Tingting Yu, Xiaolei Zhu, Xiaoyan Zou, Ying Peng, Yun Xu, Zhongzhou Yang, Guiquan Chen |
| Abstract |
Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001]. Recent evidence has shown that Akt is down-regulated in AD [J Pathol. 225:54-62, 2011]. However, it remained unknown which pathological process, e.g. tau pathology or neuron death, Akt may contribute to. In this study, Cre-loxP technique was employed to generate a viable Akt three isoforms conditional knockout (Akt cTKO) mouse in which total Akt levels were dramatically reduced in the adult brain. Significantly increased levels of tau phosphorylated (p-tau) at various sites were observed in Akt cTKO mice as compared to age-matched littermate controls. Increased levels for phosphorylated GSK3α and phosphorylated PKA substrates were detected in Akt cTKO brains. In contrast, no significant changes on p-tau levels were found in Akt1 (-/-), Akt2 (-/-) or Akt3 (-/-) mice. Akt may regulate tau phosphorylation in the adult brain by affecting activities for PKA and GSK3α. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 38 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 20% |
| Student > Ph. D. Student | 6 | 15% |
| Student > Bachelor | 6 | 15% |
| Student > Doctoral Student | 2 | 5% |
| Professor | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 10 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 25% |
| Biochemistry, Genetics and Molecular Biology | 9 | 23% |
| Agricultural and Biological Sciences | 4 | 10% |
| Medicine and Dentistry | 2 | 5% |
| Chemical Engineering | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 10 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2016.
All research outputs
#2,704,154
of 22,818,766 outputs
Outputs from Molecular Neurodegeneration
#352
of 848 outputs
Outputs of similar age
#36,103
of 262,895 outputs
Outputs of similar age from Molecular Neurodegeneration
#12
of 22 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 848 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.