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Effects of treatment with Astragalus Membranaceus on function of rat leydig cells

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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24 tweeters
facebook
1 Facebook page

Citations

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19 Dimensions

Readers on

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16 Mendeley
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Title
Effects of treatment with Astragalus Membranaceus on function of rat leydig cells
Published in
BMC Complementary Medicine and Therapies, August 2015
DOI 10.1186/s12906-015-0776-3
Pubmed ID
Authors

Xiaolong Jiang, Xia Cao, Yang Huang, Jianwei Chen, Xiaolei Yao, Miaomiao Zhao, Yan Liu, Jinzhu Meng, Pengfei Li, Zhiyan Li, Jianbo Yao, George W Smith, Lihua Lv

Abstract

Astragalus membranaceus (AM) is a Chinese traditional herb which has been reported to have broad positive effects on many diseases, including hepatitis, heart disease, diabetes and skin disease. AM can promote cell proliferation, increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and inhibit apoptosis by regulating the transcription of proto-oncogenes controlling cell death. While AM is included in some commercially available "testosterone boosting supplements", studies directly testing ability of AM to modulate testosterone production are lacking. In the present study, we examined the effects of AM on Leydig cell function in vitro. Rat Leydig cells were purified and treated with AM at different concentrations (0 μg/mL, 10 μg/mL, 20 μg/mL, 50 μg/mL, 100 μg/mL and 150 μg/mL) and cell counting-8 (CCK-8) assay, Enzyme-linked immunosorbent assay, quantitative real time PCR and analysis of activities of SOD and GPx were done respectively. Treatment with 100 μg/mL (P < 0.05) and 150 μg/mL AM (P < 0.01) significantly increased Leydig cell numbers. Treatment with AM (20 μg/mL, 50 μg/mL and 100 μg/mL) significantly increased testosterone production (P < 0.01). In addition, increased Leydig cell SOD and GPx activities were observed in response to 20 μg/mL and 50 μg/mL AM treatment (P < 0.01). Furthermore, expression of Bax mRNA was significantly decreased (P < 0.01), and the ratio of Bcl-2/Bax mRNA was significantly increased in response to 20 μg/mL AM in the culture medium (P < 0.05). Results supported a beneficial effect of AM on multiple aspects of rat Leydig cell function in vitro including testosterone production.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 13%
Lecturer 2 13%
Researcher 2 13%
Professor > Associate Professor 2 13%
Student > Master 1 6%
Other 3 19%
Unknown 4 25%
Readers by discipline Count As %
Medicine and Dentistry 4 25%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 2 13%
Nursing and Health Professions 1 6%
Unknown 7 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2017.
All research outputs
#1,699,440
of 22,818,766 outputs
Outputs from BMC Complementary Medicine and Therapies
#287
of 3,630 outputs
Outputs of similar age
#23,640
of 264,249 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#3
of 95 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.