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MVP and vaults: a role in the radiation response

Overview of attention for article published in Radiation Oncology, October 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
65 Mendeley
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Title
MVP and vaults: a role in the radiation response
Published in
Radiation Oncology, October 2011
DOI 10.1186/1748-717x-6-148
Pubmed ID
Authors

Pedro C Lara, Martin Pruschy, Martina Zimmermann, Luis Alberto Henríquez-Hernández

Abstract

Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose) polymerase (vPARP) and the 240 kDa telomerase-associated protein-1 (TEP-1). Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Norway 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 28%
Researcher 11 17%
Student > Bachelor 8 12%
Student > Doctoral Student 5 8%
Professor 4 6%
Other 9 14%
Unknown 10 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 34%
Biochemistry, Genetics and Molecular Biology 15 23%
Medicine and Dentistry 9 14%
Chemistry 2 3%
Computer Science 1 2%
Other 2 3%
Unknown 14 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2015.
All research outputs
#2,311,744
of 19,985,377 outputs
Outputs from Radiation Oncology
#53
of 1,860 outputs
Outputs of similar age
#13,969
of 130,451 outputs
Outputs of similar age from Radiation Oncology
#2
of 54 outputs
Altmetric has tracked 19,985,377 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,860 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.