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Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys

Overview of attention for article published in BMC Nephrology, July 2015
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Title
Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys
Published in
BMC Nephrology, July 2015
DOI 10.1186/s12882-015-0120-7
Pubmed ID
Authors

Anthony E. Samir, Andrew S. Allegretti, Qingli Zhu, Manish Dhyani, Arash Anvari, Dorothy A. Sullivan, Caitlin A. Trottier, Sarah Dougherty, Winfred W. Williams, Jodie L. Babitt, Julia Wenger, Ravi I. Thadhani, Herbert Y. Lin

Abstract

There currently is a need for a non-invasive measure of renal fibrosis. We aim to explore whether shear wave elastography (SWE)-derived estimates of tissue stiffness may serve as a non-invasive biomarker that can distinguish normal and abnormal renal parenchymal tissue. Participants with CKD (by estimated GFR) and healthy volunteers underwent SWE. Renal elasticity was estimated as Young's modulus (YM) in kilopascals (kPa). Univariate Wilcoxon rank-sum tests were used. Twenty-five participants with CKD (median GFR 38 mL/min; quartile 1, quartile 3 28, 42) and 20 healthy controls without CKD underwent SWE performed by a single radiologist. CKD was associated with increased median YM (9.40 [5.55, 22.35] vs. 4.40 [3.68, 5.70] kPa; p = 0.002) and higher median intra-subject inter-measurement estimated YM's variability (4.27 [2.89, 9.90] vs. 1.51 [1.21, 2.05] kPa; p < 0.001). SWE-derived estimates of renal stiffness and intra-subject estimated stiffness variability are higher in patients with CKD than in healthy controls. Renal fibrosis is a plausible explanation for the observed difference in YM. Further studies are required to determine the relationship between YM, estimated renal stiffness, and renal fibrosis severity.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 105 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 15%
Student > Ph. D. Student 13 12%
Student > Postgraduate 12 11%
Student > Master 12 11%
Student > Doctoral Student 5 5%
Other 17 16%
Unknown 31 29%
Readers by discipline Count As %
Medicine and Dentistry 34 32%
Engineering 10 9%
Nursing and Health Professions 3 3%
Materials Science 3 3%
Neuroscience 3 3%
Other 13 12%
Unknown 40 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2015.
All research outputs
#15,340,815
of 22,818,766 outputs
Outputs from BMC Nephrology
#1,446
of 2,468 outputs
Outputs of similar age
#153,591
of 262,894 outputs
Outputs of similar age from BMC Nephrology
#28
of 42 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,468 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,894 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.