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The effects of adding epinephrine to ropivacaine for popliteal nerve block on the duration of postoperative analgesia: a randomized controlled trial

Overview of attention for article published in BMC Anesthesiology, July 2015
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Title
The effects of adding epinephrine to ropivacaine for popliteal nerve block on the duration of postoperative analgesia: a randomized controlled trial
Published in
BMC Anesthesiology, July 2015
DOI 10.1186/s12871-015-0083-z
Pubmed ID
Authors

Karin P.W. Schoenmakers, Maaike G.E. Fenten, Jan Willem Louwerens, Gert Jan Scheffer, Rudolf Stienstra

Abstract

Duration of peripheral nerve blocks depends on multiple factors. Both technique and type of local anesthetic used, either with or without adjuncts, may result in different duration times of the block. The purpose of the present study was to compare the duration of postoperative analgesia of 30 mL ropivacaine 0.75 % with or without epinephrine for popliteal sciatic nerve block. Thirty-eight patients were included to receive ultrasound guided continuous popliteal nerve block with ropivacaine 0.75 % either without (ROPI) or with epinephrine 5 μg/mL (ROPI-EPI) for ankle fusion, subtalar fusion, or a combination of both. The primary outcome parameter was the duration of postoperative analgesia as reflected by the time to first request for postoperative analgesia (TTFR) through the popliteal nerve catheter. Secondary outcome measures included the onset of sensory and motor block and NRS score for pain at rest and during movement. Thirty patients, 15 in each group, were studied. Eight patients were withdrawn because of specific withdrawal criteria described in the protocol and replaced according to their group allocation. Median [interquartile range] TTFR was 463 [300-1197] min and 830 [397-1128] min for the ROPI vs ROPI-EPI group respectively. Hodges Lehman median difference between groups was 71 min (95 % CI -415 - 473 min). There was no difference in any clinical outcome measure between the groups. The results of this study did not show any significant increase in the duration of postoperative analgesia by adding epinephrine to ropivacaine for popliteal nerve block. This may be due to the intrinsic vasoconstrictive properties of ropivacaine. The absence of a significant difference can also be the result of a type II error caused by a large variation in the individual TTFR. Trial register.nl identifier: NTR3330 , keyword TTFR.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 7 11%
Student > Master 6 10%
Student > Bachelor 6 10%
Researcher 5 8%
Student > Ph. D. Student 5 8%
Other 16 26%
Unknown 16 26%
Readers by discipline Count As %
Medicine and Dentistry 31 51%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Nursing and Health Professions 3 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Psychology 1 2%
Other 3 5%
Unknown 19 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2015.
All research outputs
#20,284,384
of 22,818,766 outputs
Outputs from BMC Anesthesiology
#1,174
of 1,496 outputs
Outputs of similar age
#219,647
of 262,916 outputs
Outputs of similar age from BMC Anesthesiology
#19
of 24 outputs
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